IMSI is an advanced fertility treatment that improves on ICSI (Intracytoplasmic Sperm Injection). In IMSI, sperm are examined under a very high-powered microscope (up to 6000x magnification) to select the most healthy and morphologically normal sperm for injection into the egg.
This technique gives embryologists a much clearer view of sperm structure, helping them avoid sperm with abnormalities that might affect fertilization or embryo development.
IMSI is suggested in cases of:
• Severe male infertility (low count, poor motility, or abnormal shape).
• High levels of sperm DNA fragmentation.
• Repeated IVF/ICSI failures.
• Poor embryo quality in previous cycles.
• Unexplained infertility when other methods fail.
You should consult a fertility specialist about ICSI if you and your partner have been trying to conceive without success for 12 months (6 months if the woman is over 35) or if there are known fertility concerns. ICSI is especially recommended in the following situations:
1. Egg Retrieval – Eggs are collected from the female partner after stimulation.
2. Sperm Preparation – Sperm sample is collected and washed.
3. High-Magnification Sperm Selection – Embryologists examine sperm under a powerful microscope to pick the healthiest-looking sperm.
4. Sperm Injection– Selected sperm is injected directly into the egg (similar to ICSI).
5. Embryo Culture– Fertilized eggs are monitored in the lab.
6. Embryo Transfer– Healthy embryos are transferred into the uterus.
ICSI selects sperm at normal magnification (400x), while IMSI uses high magnification (up to 6000x) to choose sperm with the best shape and structure.
Men with poor sperm quality, high DNA fragmentation, or couples with repeated IVF/ICSI failures benefit the most.
No fertility treatment can guarantee pregnancy. However, IMSI improves the chances by using the healthiest sperm available.
Yes ✅. Studies show IMSI is safe, and babies born through IMSI are as healthy as those conceived via IVF or ICSI.
Success varies depending on age, egg quality, and sperm condition, but many clinics report higher implantation and pregnancy rates in IMSI compared to ICSI for selected patients.
With Fertylity IVF in Delhi, we distinguish ourselves by offering personalized care and treatment for infertility. We focus on a holistic evaluation of each couple, blending expert clinical care with comfort and advanced technology.
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